Towards a Unified Testing Framework for Single-Sided Deafness Studies: A Consensus Paper
Identifieur interne : 000150 ( Main/Exploration ); précédent : 000149; suivant : 000151Towards a Unified Testing Framework for Single-Sided Deafness Studies: A Consensus Paper
Auteurs : Paul Van De Heyning [Belgique] ; Dayse Távora-Vieira [Australie] ; Griet Mertens [Belgique] ; Vincent Van Rompaey [Belgique] ; Gunesh P. Rajan [Australie] ; Joachim Müller [Allemagne] ; John Martin Hempel [Allemagne] ; Daniel Leander [Allemagne] ; Daniel Polterauer [Allemagne] ; Mathieu Marx [France] ; Shin-Ichi Usami [Japon] ; Ryosuke Kitoh [Japon] ; Maiko Miyagawa [Japon] ; Hideaki Moteki [Japon] ; Kari Smilsky [Canada] ; Wolf-Dieter Baumgartner [Autriche] ; Thomas Georg Keintzel [Pays-Bas] ; Georg Mathias Sprinzl [Pays-Bas] ; Astrid Wolf-Magele [Pays-Bas] ; Susan Arndt [Pays-Bas] ; Thomas Wesarg [Pays-Bas] ; Stefan Zirn [Pays-Bas] ; Uwe Baumann [Pays-Bas] ; Tobias Weissgerber [Pays-Bas] ; Tobias Rader [Pays-Bas] ; Rudolf Hagen [Pays-Bas] ; Anja Kurz [Pays-Bas] ; Kristen Rak [Pays-Bas] ; Robert Stokroos [Pays-Bas] ; Erwin George [Pays-Bas] ; Ruben Polo [Espagne] ; María Del Mar Medina [Espagne] ; Yael Henkin ; Ohad Hilly [Israël] ; David Ulanovski [Israël] ; Ranjith Rajeswaran [Argentine] ; Mohan Kameswaran [Argentine] ; Maria Fernanda Di Gregorio [Argentine] ; Mario E. Zernotti [Argentine]Source :
- Audiology & Neurotology [ 1420-3030 ] ; 2017.
Abstract
While hearing aids for a contralateral routing of signals (CROS-HA) and bone conduction devices have been the traditional treatment for single-sided deafness (SSD) and asymmetric hearing loss (AHL), in recent years, cochlear implants (CIs) have increasingly become a viable treatment choice, particularly in countries where regulatory approval and reimbursement schemes are in place. Part of the reason for this shift is that the CI is the only device capable of restoring bilateral input to the auditory system and hence of possibly reinstating binaural hearing. Although several studies have independently shown that the CI is a safe and effective treatment for SSD and AHL, clinical outcome measures in those studies and across CI centers vary greatly. Only with a consistent use of defined and agreed-upon outcome measures across centers can high-level evidence be generated to assess the safety and efficacy of CIs and alternative treatments in recipients with SSD and AHL.
This paper presents a comparative study design and minimum outcome measures for the assessment of current treatment options in patients with SSD/AHL. The protocol was developed, discussed, and eventually agreed upon by expert panels that convened at the 2015 APSCI conference in Beijing, China, and at the CI 2016 conference in Toronto, Canada.
A longitudinal study design comparing CROS-HA, BCD, and CI treatments is proposed. The recommended outcome measures include (1) speech in noise testing, using the same set of 3 spatial configurations to compare binaural benefits such as summation, squelch, and head shadow across devices; (2) localization testing, using stimuli that rove in both level and spectral content; (3) questionnaires to collect quality of life measures and the frequency of device use; and (4) questionnaires for assessing the impact of tinnitus before and after treatment, if applicable.
A protocol for the assessment of treatment options and outcomes in recipients with SSD and AHL is presented. The proposed set of minimum outcome measures aims at harmonizing assessment methods across centers and thus at generating a growing body of high-level evidence for those treatment options.
Url:
DOI: 10.1159/000455058
PubMed: 28319951
PubMed Central: 5472212
Affiliations:
- Allemagne, Argentine, Australie, Autriche, Belgique, Canada, Espagne, France, Israël, Japon, Pays-Bas
- Bavière, Communauté de Madrid, District de Haute-Bavière, Midi-Pyrénées, Occitanie (région administrative), Ontario, Province d'Anvers, Région flamande, Vienne (Autriche)
- Anvers, Madrid, Munich, Toronto, Toulouse, Vienne (Autriche)
- Université d'Anvers, Université de Toronto
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Rajan</name><affiliation wicri:level="1"><nlm:aff id="aff3">Otolaryngology, Head and Neck Surgery, School of Surgery, University of Western Australia, WA, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Otolaryngology, Head and Neck Surgery, School of Surgery, University of Western Australia, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4">Fiona Stanley Hospital, Perth, WA, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Fiona Stanley Hospital, Perth, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation></author><author><name sortKey="Muller, Joachim" sort="Muller, Joachim" uniqKey="Muller J" first="Joachim" last="Müller">Joachim Müller</name><affiliation wicri:level="3"><nlm:aff id="aff5">Ear, Nose and Throat Clinic and Policlinic, Ludwig Maximilian University, Munich, Germany</nlm:aff><country 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Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Ear, Nose and Throat Clinic and Policlinic, Ludwig Maximilian University, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Marx, Mathieu" sort="Marx, Mathieu" uniqKey="Marx M" first="Mathieu" last="Marx">Mathieu Marx</name><affiliation wicri:level="3"><nlm:aff id="aff6">Department of Otology-Neurotology and Skull Base Surgery, Hôpital Purpan, Toulouse, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Otology-Neurotology and Skull Base Surgery, Hôpital Purpan, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Usami, Shin Ichi" sort="Usami, Shin Ichi" uniqKey="Usami S" first="Shin-Ichi" last="Usami">Shin-Ichi Usami</name><affiliation wicri:level="1"><nlm:aff id="aff7">Otorhinolaryngology, Shinshu University School of Medicine, Matsumoto, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Otorhinolaryngology, Shinshu University School of Medicine, Matsumoto</wicri:regionArea><wicri:noRegion>Matsumoto</wicri:noRegion></affiliation></author><author><name sortKey="Kitoh, Ryosuke" sort="Kitoh, Ryosuke" uniqKey="Kitoh R" first="Ryosuke" last="Kitoh">Ryosuke Kitoh</name><affiliation wicri:level="1"><nlm:aff id="aff7">Otorhinolaryngology, Shinshu University School of Medicine, Matsumoto, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Otorhinolaryngology, Shinshu University School of Medicine, Matsumoto</wicri:regionArea><wicri:noRegion>Matsumoto</wicri:noRegion></affiliation></author><author><name sortKey="Miyagawa, Maiko" sort="Miyagawa, Maiko" uniqKey="Miyagawa M" first="Maiko" last="Miyagawa">Maiko Miyagawa</name><affiliation wicri:level="1"><nlm:aff id="aff8">Hearing Implant Sciences, Shinshu University School of Medicine, Matsumoto, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Hearing Implant Sciences, Shinshu University School of Medicine, Matsumoto</wicri:regionArea><wicri:noRegion>Matsumoto</wicri:noRegion></affiliation></author><author><name sortKey="Moteki, Hideaki" sort="Moteki, Hideaki" uniqKey="Moteki H" first="Hideaki" last="Moteki">Hideaki Moteki</name><affiliation wicri:level="1"><nlm:aff id="aff7">Otorhinolaryngology, Shinshu University School of Medicine, Matsumoto, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Otorhinolaryngology, Shinshu University School of Medicine, Matsumoto</wicri:regionArea><wicri:noRegion>Matsumoto</wicri:noRegion></affiliation></author><author><name sortKey="Smilsky, Kari" sort="Smilsky, Kari" uniqKey="Smilsky K" first="Kari" last="Smilsky">Kari Smilsky</name><affiliation wicri:level="4"><nlm:aff id="aff9">Department of Otolaryngology, Head and Neck Surgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Otolaryngology, Head and Neck Surgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Baumgartner, Wolf Dieter" sort="Baumgartner, Wolf Dieter" uniqKey="Baumgartner W" first="Wolf-Dieter" last="Baumgartner">Wolf-Dieter Baumgartner</name><affiliation wicri:level="3"><nlm:aff id="aff10">Ear, Nose and Throat Department, University Clinic Vienna, Vienna</nlm:aff><country>Autriche</country><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName><wicri:orgArea>Ear, Nose and Throat Department, University Clinic Vienna</wicri:orgArea></affiliation></author><author><name sortKey="Keintzel, Thomas Georg" sort="Keintzel, Thomas Georg" uniqKey="Keintzel T" first="Thomas Georg" last="Keintzel">Thomas Georg Keintzel</name><affiliation wicri:level="1"><nlm:aff id="aff11">Department of Otorhinolaryngology, Klinikum Wels-Grieskirchen GmbH, Wels, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Otorhinolaryngology, Klinikum Wels-Grieskirchen GmbH, Wels</wicri:regionArea><wicri:noRegion>Wels</wicri:noRegion></affiliation></author><author><name sortKey="Sprinzl, Georg Mathias" sort="Sprinzl, Georg Mathias" uniqKey="Sprinzl G" first="Georg Mathias" last="Sprinzl">Georg Mathias Sprinzl</name><affiliation wicri:level="1"><nlm:aff id="aff12">Department of Otorhinolaryngology, University Clinic St. Pölten, St. Pölten, Austria, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Otorhinolaryngology, University Clinic St. Pölten, St. Pölten, Austria</wicri:regionArea><wicri:noRegion>Austria</wicri:noRegion></affiliation></author><author><name sortKey="Wolf Magele, Astrid" sort="Wolf Magele, Astrid" uniqKey="Wolf Magele A" first="Astrid" last="Wolf-Magele">Astrid Wolf-Magele</name><affiliation wicri:level="1"><nlm:aff id="aff12">Department of Otorhinolaryngology, University Clinic St. Pölten, St. Pölten, Austria, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Otorhinolaryngology, University Clinic St. Pölten, St. Pölten, Austria</wicri:regionArea><wicri:noRegion>Austria</wicri:noRegion></affiliation></author><author><name sortKey="Arndt, Susan" sort="Arndt, Susan" uniqKey="Arndt S" first="Susan" last="Arndt">Susan Arndt</name><affiliation wicri:level="1"><nlm:aff id="aff13">Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Freiburg, Freiburg, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Freiburg, Freiburg</wicri:regionArea><wicri:noRegion>Freiburg</wicri:noRegion></affiliation></author><author><name sortKey="Wesarg, Thomas" sort="Wesarg, Thomas" uniqKey="Wesarg T" first="Thomas" last="Wesarg">Thomas Wesarg</name><affiliation wicri:level="1"><nlm:aff id="aff13">Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Freiburg, Freiburg, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Freiburg, Freiburg</wicri:regionArea><wicri:noRegion>Freiburg</wicri:noRegion></affiliation></author><author><name sortKey="Zirn, Stefan" sort="Zirn, Stefan" uniqKey="Zirn S" first="Stefan" last="Zirn">Stefan Zirn</name><affiliation wicri:level="1"><nlm:aff id="aff13">Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Freiburg, Freiburg, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Freiburg, Freiburg</wicri:regionArea><wicri:noRegion>Freiburg</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff14">University of Applied Sciences Offenburg, Faculty of Electrical Engineering and Information Engineering, Offenburg, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>University of Applied Sciences Offenburg, Faculty of Electrical Engineering and Information Engineering, Offenburg</wicri:regionArea><wicri:noRegion>Offenburg</wicri:noRegion></affiliation></author><author><name sortKey="Baumann, Uwe" sort="Baumann, Uwe" uniqKey="Baumann U" first="Uwe" last="Baumann">Uwe Baumann</name><affiliation wicri:level="1"><nlm:aff id="aff15">Audiological Acoustics, ENT Department, University Hospital Frankfurt, Frankfurt, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Audiological Acoustics, ENT Department, University Hospital Frankfurt, Frankfurt</wicri:regionArea><wicri:noRegion>Frankfurt</wicri:noRegion></affiliation></author><author><name sortKey="Weissgerber, Tobias" sort="Weissgerber, Tobias" uniqKey="Weissgerber T" first="Tobias" last="Weissgerber">Tobias Weissgerber</name><affiliation wicri:level="1"><nlm:aff id="aff15">Audiological Acoustics, ENT Department, University Hospital Frankfurt, Frankfurt, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Audiological Acoustics, ENT Department, University Hospital Frankfurt, Frankfurt</wicri:regionArea><wicri:noRegion>Frankfurt</wicri:noRegion></affiliation></author><author><name sortKey="Rader, Tobias" sort="Rader, Tobias" uniqKey="Rader T" first="Tobias" last="Rader">Tobias Rader</name><affiliation wicri:level="1"><nlm:aff id="aff16">Department of Otolaryngology, Head and Neck Surgery, University of Mainz, Mainz, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Otolaryngology, Head and Neck Surgery, University of Mainz, Mainz</wicri:regionArea><wicri:noRegion>Mainz</wicri:noRegion></affiliation></author><author><name sortKey="Hagen, Rudolf" sort="Hagen, Rudolf" uniqKey="Hagen R" first="Rudolf" last="Hagen">Rudolf Hagen</name><affiliation wicri:level="1"><nlm:aff id="aff17">Department of Otolaryngology, University Hospital Würzburg, Würzburg, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Otolaryngology, University Hospital Würzburg, Würzburg</wicri:regionArea><wicri:noRegion>Würzburg</wicri:noRegion></affiliation></author><author><name sortKey="Kurz, Anja" sort="Kurz, Anja" uniqKey="Kurz A" first="Anja" last="Kurz">Anja Kurz</name><affiliation wicri:level="1"><nlm:aff id="aff17">Department of Otolaryngology, University Hospital Würzburg, Würzburg, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Otolaryngology, University Hospital Würzburg, Würzburg</wicri:regionArea><wicri:noRegion>Würzburg</wicri:noRegion></affiliation></author><author><name sortKey="Rak, Kristen" sort="Rak, Kristen" uniqKey="Rak K" first="Kristen" last="Rak">Kristen Rak</name><affiliation wicri:level="1"><nlm:aff id="aff17">Department of Otolaryngology, University Hospital Würzburg, Würzburg, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Otolaryngology, University Hospital Würzburg, Würzburg</wicri:regionArea><wicri:noRegion>Würzburg</wicri:noRegion></affiliation></author><author><name sortKey="Stokroos, Robert" sort="Stokroos, Robert" uniqKey="Stokroos R" first="Robert" last="Stokroos">Robert Stokroos</name><affiliation wicri:level="1"><nlm:aff id="aff18">Department of Otorhinolaryngology, Head and Neck Surgery, Maastricht University Medical Center, Maastricht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Otorhinolaryngology, Head and Neck Surgery, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="George, Erwin" sort="George, Erwin" uniqKey="George E" first="Erwin" last="George">Erwin George</name><affiliation wicri:level="1"><nlm:aff id="aff18">Department of Otorhinolaryngology, Head and Neck Surgery, Maastricht University Medical Center, Maastricht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Otorhinolaryngology, Head and Neck Surgery, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Polo, Ruben" sort="Polo, Ruben" uniqKey="Polo R" first="Ruben" last="Polo">Ruben Polo</name><affiliation wicri:level="3"><nlm:aff id="aff19">Otolaryngology and Head and Neck Surgery Department, Hospital Universitario Ramón y Cajal, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Otolaryngology and Head and Neck Surgery Department, Hospital Universitario Ramón y Cajal, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Medina, Maria Del Mar" sort="Medina, Maria Del Mar" uniqKey="Medina M" first="María Del Mar" last="Medina">María Del Mar Medina</name><affiliation wicri:level="3"><nlm:aff id="aff19">Otolaryngology and Head and Neck Surgery Department, Hospital Universitario Ramón y Cajal, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Otolaryngology and Head and Neck Surgery Department, Hospital Universitario Ramón y Cajal, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Henkin, Yael" sort="Henkin, Yael" uniqKey="Henkin Y" first="Yael" last="Henkin">Yael Henkin</name><affiliation><nlm:aff id="aff20">Department of Communication Disorders, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, and The Hearing, Speech & Language Center, Sheba Medical Center, Tel Hashomer</nlm:aff><wicri:noCountry code="subfield">Tel Hashomer</wicri:noCountry></affiliation></author><author><name sortKey="Hilly, Ohad" sort="Hilly, Ohad" uniqKey="Hilly O" first="Ohad" last="Hilly">Ohad Hilly</name><affiliation wicri:level="1"><nlm:aff id="aff21">Pediatric ENT Unit, Schneider Children's Hospital, Petach Tikva and Tel Aviv University, Tel Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Pediatric ENT Unit, Schneider Children's Hospital, Petach Tikva and Tel Aviv University, Tel Aviv</wicri:regionArea><wicri:noRegion>Tel Aviv</wicri:noRegion></affiliation></author><author><name sortKey="Ulanovski, David" sort="Ulanovski, David" uniqKey="Ulanovski D" first="David" last="Ulanovski">David Ulanovski</name><affiliation wicri:level="1"><nlm:aff id="aff21">Pediatric ENT Unit, Schneider Children's Hospital, Petach Tikva and Tel Aviv University, Tel Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Pediatric ENT Unit, Schneider Children's Hospital, Petach Tikva and Tel Aviv University, Tel Aviv</wicri:regionArea><wicri:noRegion>Tel Aviv</wicri:noRegion></affiliation></author><author><name sortKey="Rajeswaran, Ranjith" sort="Rajeswaran, Ranjith" uniqKey="Rajeswaran R" first="Ranjith" last="Rajeswaran">Ranjith Rajeswaran</name><affiliation wicri:level="1"><nlm:aff id="aff22">Madras ENT Research Foundation, Chennai, India, Córdoba, Argentina</nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Madras ENT Research Foundation, Chennai, India, Córdoba</wicri:regionArea><wicri:noRegion>Córdoba</wicri:noRegion></affiliation></author><author><name sortKey="Kameswaran, Mohan" sort="Kameswaran, Mohan" uniqKey="Kameswaran M" first="Mohan" last="Kameswaran">Mohan Kameswaran</name><affiliation wicri:level="1"><nlm:aff id="aff22">Madras ENT Research Foundation, Chennai, India, Córdoba, Argentina</nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Madras ENT Research Foundation, Chennai, India, Córdoba</wicri:regionArea><wicri:noRegion>Córdoba</wicri:noRegion></affiliation></author><author><name sortKey="Di Gregorio, Maria Fernanda" sort="Di Gregorio, Maria Fernanda" uniqKey="Di Gregorio M" first="Maria Fernanda" last="Di Gregorio">Maria Fernanda Di Gregorio</name><affiliation wicri:level="1"><nlm:aff id="aff23">Department of Otoneurology, Sanatorio Allende, Córdoba, Argentina</nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Department of Otoneurology, Sanatorio Allende, Córdoba</wicri:regionArea><wicri:noRegion>Córdoba</wicri:noRegion></affiliation></author><author><name sortKey="Zernotti, Mario E" sort="Zernotti, Mario E" uniqKey="Zernotti M" first="Mario E." last="Zernotti">Mario E. Zernotti</name><affiliation wicri:level="1"><nlm:aff id="aff24">Department of Otolaryngology, Catholic University of Córdoba, Córdoba, Argentina</nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Department of Otolaryngology, Catholic University of Córdoba, Córdoba</wicri:regionArea><wicri:noRegion>Córdoba</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28319951</idno><idno type="pmc">5472212</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472212</idno><idno type="RBID">PMC:5472212</idno><idno type="doi">10.1159/000455058</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">001759</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001759</idno><idno type="wicri:Area/Pmc/Curation">001619</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001619</idno><idno type="wicri:Area/Pmc/Checkpoint">000033</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000033</idno><idno type="wicri:Area/Ncbi/Merge">004494</idno><idno type="wicri:Area/Ncbi/Curation">004494</idno><idno type="wicri:Area/Ncbi/Checkpoint">004494</idno><idno type="wicri:doubleKey">1420-3030:2017:Van De Heyning P:towards:a:unified</idno><idno type="wicri:Area/Main/Merge">000145</idno><idno type="wicri:Area/Main/Curation">000150</idno><idno type="wicri:Area/Main/Exploration">000150</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Towards a Unified Testing Framework for Single-Sided Deafness Studies: A Consensus Paper</title><author><name sortKey="Van De Heyning, Paul" sort="Van De Heyning, Paul" uniqKey="Van De Heyning P" first="Paul" last="Van De Heyning">Paul Van De Heyning</name><affiliation wicri:level="1"><nlm:aff id="aff1">University Department of Otorhinolaryngology, Head and Neck Surgery, Antwerp University Hospital, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>University Department of Otorhinolaryngology, Head and Neck Surgery, Antwerp University Hospital, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2">University of Antwerp, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>University of Antwerp, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Tavora Vieira, Dayse" sort="Tavora Vieira, Dayse" uniqKey="Tavora Vieira D" first="Dayse" last="Távora-Vieira">Dayse Távora-Vieira</name><affiliation wicri:level="1"><nlm:aff id="aff3">Otolaryngology, Head and Neck Surgery, School of Surgery, University of Western Australia, WA, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Otolaryngology, Head and Neck Surgery, School of Surgery, University of Western Australia, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4">Fiona Stanley Hospital, Perth, WA, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Fiona Stanley Hospital, Perth, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation></author><author><name sortKey="Mertens, Griet" sort="Mertens, Griet" uniqKey="Mertens G" first="Griet" last="Mertens">Griet Mertens</name><affiliation wicri:level="1"><nlm:aff id="aff1">University Department of Otorhinolaryngology, Head and Neck Surgery, Antwerp University Hospital, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>University Department of Otorhinolaryngology, Head and Neck Surgery, Antwerp University Hospital, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2">University of Antwerp, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>University of Antwerp, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Van Rompaey, Vincent" sort="Van Rompaey, Vincent" uniqKey="Van Rompaey V" first="Vincent" last="Van Rompaey">Vincent Van Rompaey</name><affiliation wicri:level="1"><nlm:aff id="aff1">University Department of Otorhinolaryngology, Head and Neck Surgery, Antwerp University Hospital, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>University Department of Otorhinolaryngology, Head and Neck Surgery, Antwerp University Hospital, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2">University of Antwerp, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>University of Antwerp, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Rajan, Gunesh P" sort="Rajan, Gunesh P" uniqKey="Rajan G" first="Gunesh P." last="Rajan">Gunesh P. Rajan</name><affiliation wicri:level="1"><nlm:aff id="aff3">Otolaryngology, Head and Neck Surgery, School of Surgery, University of Western Australia, WA, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Otolaryngology, Head and Neck Surgery, School of Surgery, University of Western Australia, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4">Fiona Stanley Hospital, Perth, WA, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Fiona Stanley Hospital, Perth, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation></author><author><name sortKey="Muller, Joachim" sort="Muller, Joachim" uniqKey="Muller J" first="Joachim" last="Müller">Joachim Müller</name><affiliation wicri:level="3"><nlm:aff id="aff5">Ear, Nose and Throat Clinic and Policlinic, Ludwig Maximilian University, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Ear, Nose and Throat Clinic and Policlinic, Ludwig Maximilian University, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Hempel, John Martin" sort="Hempel, John Martin" uniqKey="Hempel J" first="John Martin" last="Hempel">John Martin Hempel</name><affiliation wicri:level="3"><nlm:aff id="aff5">Ear, Nose and Throat Clinic and Policlinic, Ludwig Maximilian University, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Ear, Nose and Throat Clinic and Policlinic, Ludwig Maximilian University, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Leander, Daniel" sort="Leander, Daniel" uniqKey="Leander D" first="Daniel" last="Leander">Daniel Leander</name><affiliation wicri:level="3"><nlm:aff id="aff5">Ear, Nose and Throat Clinic and Policlinic, Ludwig Maximilian University, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Ear, Nose and Throat Clinic and Policlinic, Ludwig Maximilian University, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Polterauer, Daniel" sort="Polterauer, Daniel" uniqKey="Polterauer D" first="Daniel" last="Polterauer">Daniel Polterauer</name><affiliation wicri:level="3"><nlm:aff id="aff5">Ear, Nose and Throat Clinic and Policlinic, Ludwig Maximilian University, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Ear, Nose and Throat Clinic and Policlinic, Ludwig Maximilian University, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Marx, Mathieu" sort="Marx, Mathieu" uniqKey="Marx M" first="Mathieu" last="Marx">Mathieu Marx</name><affiliation wicri:level="3"><nlm:aff id="aff6">Department of Otology-Neurotology and Skull Base Surgery, Hôpital Purpan, Toulouse, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Otology-Neurotology and Skull Base Surgery, Hôpital Purpan, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Usami, Shin Ichi" sort="Usami, Shin Ichi" uniqKey="Usami S" first="Shin-Ichi" last="Usami">Shin-Ichi Usami</name><affiliation wicri:level="1"><nlm:aff id="aff7">Otorhinolaryngology, Shinshu University School of Medicine, Matsumoto, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Otorhinolaryngology, Shinshu University School of Medicine, Matsumoto</wicri:regionArea><wicri:noRegion>Matsumoto</wicri:noRegion></affiliation></author><author><name sortKey="Kitoh, Ryosuke" sort="Kitoh, Ryosuke" uniqKey="Kitoh R" first="Ryosuke" last="Kitoh">Ryosuke Kitoh</name><affiliation wicri:level="1"><nlm:aff id="aff7">Otorhinolaryngology, Shinshu University School of Medicine, Matsumoto, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Otorhinolaryngology, Shinshu University School of Medicine, Matsumoto</wicri:regionArea><wicri:noRegion>Matsumoto</wicri:noRegion></affiliation></author><author><name sortKey="Miyagawa, Maiko" sort="Miyagawa, Maiko" uniqKey="Miyagawa M" first="Maiko" last="Miyagawa">Maiko Miyagawa</name><affiliation wicri:level="1"><nlm:aff id="aff8">Hearing Implant Sciences, Shinshu University School of Medicine, Matsumoto, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Hearing Implant Sciences, Shinshu University School of Medicine, Matsumoto</wicri:regionArea><wicri:noRegion>Matsumoto</wicri:noRegion></affiliation></author><author><name sortKey="Moteki, Hideaki" sort="Moteki, Hideaki" uniqKey="Moteki H" first="Hideaki" last="Moteki">Hideaki Moteki</name><affiliation wicri:level="1"><nlm:aff id="aff7">Otorhinolaryngology, Shinshu University School of Medicine, Matsumoto, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Otorhinolaryngology, Shinshu University School of Medicine, Matsumoto</wicri:regionArea><wicri:noRegion>Matsumoto</wicri:noRegion></affiliation></author><author><name sortKey="Smilsky, Kari" sort="Smilsky, Kari" uniqKey="Smilsky K" first="Kari" last="Smilsky">Kari Smilsky</name><affiliation wicri:level="4"><nlm:aff id="aff9">Department of Otolaryngology, Head and Neck Surgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Otolaryngology, Head and Neck Surgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Baumgartner, Wolf Dieter" sort="Baumgartner, Wolf Dieter" uniqKey="Baumgartner W" first="Wolf-Dieter" last="Baumgartner">Wolf-Dieter Baumgartner</name><affiliation wicri:level="3"><nlm:aff id="aff10">Ear, Nose and Throat Department, University Clinic Vienna, Vienna</nlm:aff><country>Autriche</country><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName><wicri:orgArea>Ear, Nose and Throat Department, University Clinic Vienna</wicri:orgArea></affiliation></author><author><name sortKey="Keintzel, Thomas Georg" sort="Keintzel, Thomas Georg" uniqKey="Keintzel T" first="Thomas Georg" last="Keintzel">Thomas Georg Keintzel</name><affiliation wicri:level="1"><nlm:aff id="aff11">Department of Otorhinolaryngology, Klinikum Wels-Grieskirchen GmbH, Wels, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Otorhinolaryngology, Klinikum Wels-Grieskirchen GmbH, Wels</wicri:regionArea><wicri:noRegion>Wels</wicri:noRegion></affiliation></author><author><name sortKey="Sprinzl, Georg Mathias" sort="Sprinzl, Georg Mathias" uniqKey="Sprinzl G" first="Georg Mathias" last="Sprinzl">Georg Mathias Sprinzl</name><affiliation wicri:level="1"><nlm:aff id="aff12">Department of Otorhinolaryngology, University Clinic St. Pölten, St. Pölten, Austria, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Otorhinolaryngology, University Clinic St. Pölten, St. Pölten, Austria</wicri:regionArea><wicri:noRegion>Austria</wicri:noRegion></affiliation></author><author><name sortKey="Wolf Magele, Astrid" sort="Wolf Magele, Astrid" uniqKey="Wolf Magele A" first="Astrid" last="Wolf-Magele">Astrid Wolf-Magele</name><affiliation wicri:level="1"><nlm:aff id="aff12">Department of Otorhinolaryngology, University Clinic St. Pölten, St. Pölten, Austria, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Otorhinolaryngology, University Clinic St. Pölten, St. Pölten, Austria</wicri:regionArea><wicri:noRegion>Austria</wicri:noRegion></affiliation></author><author><name sortKey="Arndt, Susan" sort="Arndt, Susan" uniqKey="Arndt S" first="Susan" last="Arndt">Susan Arndt</name><affiliation wicri:level="1"><nlm:aff id="aff13">Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Freiburg, Freiburg, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Freiburg, Freiburg</wicri:regionArea><wicri:noRegion>Freiburg</wicri:noRegion></affiliation></author><author><name sortKey="Wesarg, Thomas" sort="Wesarg, Thomas" uniqKey="Wesarg T" first="Thomas" last="Wesarg">Thomas Wesarg</name><affiliation wicri:level="1"><nlm:aff id="aff13">Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Freiburg, Freiburg, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Freiburg, Freiburg</wicri:regionArea><wicri:noRegion>Freiburg</wicri:noRegion></affiliation></author><author><name sortKey="Zirn, Stefan" sort="Zirn, Stefan" uniqKey="Zirn S" first="Stefan" last="Zirn">Stefan Zirn</name><affiliation wicri:level="1"><nlm:aff id="aff13">Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Freiburg, Freiburg, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Freiburg, Freiburg</wicri:regionArea><wicri:noRegion>Freiburg</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff14">University of Applied Sciences Offenburg, Faculty of Electrical Engineering and Information Engineering, Offenburg, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>University of Applied Sciences Offenburg, Faculty of Electrical Engineering and Information Engineering, Offenburg</wicri:regionArea><wicri:noRegion>Offenburg</wicri:noRegion></affiliation></author><author><name sortKey="Baumann, Uwe" sort="Baumann, Uwe" uniqKey="Baumann U" first="Uwe" last="Baumann">Uwe Baumann</name><affiliation wicri:level="1"><nlm:aff id="aff15">Audiological Acoustics, ENT Department, University Hospital Frankfurt, Frankfurt, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Audiological Acoustics, ENT Department, University Hospital Frankfurt, Frankfurt</wicri:regionArea><wicri:noRegion>Frankfurt</wicri:noRegion></affiliation></author><author><name sortKey="Weissgerber, Tobias" sort="Weissgerber, Tobias" uniqKey="Weissgerber T" first="Tobias" last="Weissgerber">Tobias Weissgerber</name><affiliation wicri:level="1"><nlm:aff id="aff15">Audiological Acoustics, ENT Department, University Hospital Frankfurt, Frankfurt, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Audiological Acoustics, ENT Department, University Hospital Frankfurt, Frankfurt</wicri:regionArea><wicri:noRegion>Frankfurt</wicri:noRegion></affiliation></author><author><name sortKey="Rader, Tobias" sort="Rader, Tobias" uniqKey="Rader T" first="Tobias" last="Rader">Tobias Rader</name><affiliation wicri:level="1"><nlm:aff id="aff16">Department of Otolaryngology, Head and Neck Surgery, University of Mainz, Mainz, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Otolaryngology, Head and Neck Surgery, University of Mainz, Mainz</wicri:regionArea><wicri:noRegion>Mainz</wicri:noRegion></affiliation></author><author><name sortKey="Hagen, Rudolf" sort="Hagen, Rudolf" uniqKey="Hagen R" first="Rudolf" last="Hagen">Rudolf Hagen</name><affiliation wicri:level="1"><nlm:aff id="aff17">Department of Otolaryngology, University Hospital Würzburg, Würzburg, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Otolaryngology, University Hospital Würzburg, Würzburg</wicri:regionArea><wicri:noRegion>Würzburg</wicri:noRegion></affiliation></author><author><name sortKey="Kurz, Anja" sort="Kurz, Anja" uniqKey="Kurz A" first="Anja" last="Kurz">Anja Kurz</name><affiliation wicri:level="1"><nlm:aff id="aff17">Department of Otolaryngology, University Hospital Würzburg, Würzburg, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Otolaryngology, University Hospital Würzburg, Würzburg</wicri:regionArea><wicri:noRegion>Würzburg</wicri:noRegion></affiliation></author><author><name sortKey="Rak, Kristen" sort="Rak, Kristen" uniqKey="Rak K" first="Kristen" last="Rak">Kristen Rak</name><affiliation wicri:level="1"><nlm:aff id="aff17">Department of Otolaryngology, University Hospital Würzburg, Würzburg, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Otolaryngology, University Hospital Würzburg, Würzburg</wicri:regionArea><wicri:noRegion>Würzburg</wicri:noRegion></affiliation></author><author><name sortKey="Stokroos, Robert" sort="Stokroos, Robert" uniqKey="Stokroos R" first="Robert" last="Stokroos">Robert Stokroos</name><affiliation wicri:level="1"><nlm:aff id="aff18">Department of Otorhinolaryngology, Head and Neck Surgery, Maastricht University Medical Center, Maastricht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Otorhinolaryngology, Head and Neck Surgery, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="George, Erwin" sort="George, Erwin" uniqKey="George E" first="Erwin" last="George">Erwin George</name><affiliation wicri:level="1"><nlm:aff id="aff18">Department of Otorhinolaryngology, Head and Neck Surgery, Maastricht University Medical Center, Maastricht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Otorhinolaryngology, Head and Neck Surgery, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Polo, Ruben" sort="Polo, Ruben" uniqKey="Polo R" first="Ruben" last="Polo">Ruben Polo</name><affiliation wicri:level="3"><nlm:aff id="aff19">Otolaryngology and Head and Neck Surgery Department, Hospital Universitario Ramón y Cajal, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Otolaryngology and Head and Neck Surgery Department, Hospital Universitario Ramón y Cajal, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Medina, Maria Del Mar" sort="Medina, Maria Del Mar" uniqKey="Medina M" first="María Del Mar" last="Medina">María Del Mar Medina</name><affiliation wicri:level="3"><nlm:aff id="aff19">Otolaryngology and Head and Neck Surgery Department, Hospital Universitario Ramón y Cajal, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Otolaryngology and Head and Neck Surgery Department, Hospital Universitario Ramón y Cajal, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Henkin, Yael" sort="Henkin, Yael" uniqKey="Henkin Y" first="Yael" last="Henkin">Yael Henkin</name><affiliation><nlm:aff id="aff20">Department of Communication Disorders, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, and The Hearing, Speech & Language Center, Sheba Medical Center, Tel Hashomer</nlm:aff><wicri:noCountry code="subfield">Tel Hashomer</wicri:noCountry></affiliation></author><author><name sortKey="Hilly, Ohad" sort="Hilly, Ohad" uniqKey="Hilly O" first="Ohad" last="Hilly">Ohad Hilly</name><affiliation wicri:level="1"><nlm:aff id="aff21">Pediatric ENT Unit, Schneider Children's Hospital, Petach Tikva and Tel Aviv University, Tel Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Pediatric ENT Unit, Schneider Children's Hospital, Petach Tikva and Tel Aviv University, Tel Aviv</wicri:regionArea><wicri:noRegion>Tel Aviv</wicri:noRegion></affiliation></author><author><name sortKey="Ulanovski, David" sort="Ulanovski, David" uniqKey="Ulanovski D" first="David" last="Ulanovski">David Ulanovski</name><affiliation wicri:level="1"><nlm:aff id="aff21">Pediatric ENT Unit, Schneider Children's Hospital, Petach Tikva and Tel Aviv University, Tel Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Pediatric ENT Unit, Schneider Children's Hospital, Petach Tikva and Tel Aviv University, Tel Aviv</wicri:regionArea><wicri:noRegion>Tel Aviv</wicri:noRegion></affiliation></author><author><name sortKey="Rajeswaran, Ranjith" sort="Rajeswaran, Ranjith" uniqKey="Rajeswaran R" first="Ranjith" last="Rajeswaran">Ranjith Rajeswaran</name><affiliation wicri:level="1"><nlm:aff id="aff22">Madras ENT Research Foundation, Chennai, India, Córdoba, Argentina</nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Madras ENT Research Foundation, Chennai, India, Córdoba</wicri:regionArea><wicri:noRegion>Córdoba</wicri:noRegion></affiliation></author><author><name sortKey="Kameswaran, Mohan" sort="Kameswaran, Mohan" uniqKey="Kameswaran M" first="Mohan" last="Kameswaran">Mohan Kameswaran</name><affiliation wicri:level="1"><nlm:aff id="aff22">Madras ENT Research Foundation, Chennai, India, Córdoba, Argentina</nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Madras ENT Research Foundation, Chennai, India, Córdoba</wicri:regionArea><wicri:noRegion>Córdoba</wicri:noRegion></affiliation></author><author><name sortKey="Di Gregorio, Maria Fernanda" sort="Di Gregorio, Maria Fernanda" uniqKey="Di Gregorio M" first="Maria Fernanda" last="Di Gregorio">Maria Fernanda Di Gregorio</name><affiliation wicri:level="1"><nlm:aff id="aff23">Department of Otoneurology, Sanatorio Allende, Córdoba, Argentina</nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Department of Otoneurology, Sanatorio Allende, Córdoba</wicri:regionArea><wicri:noRegion>Córdoba</wicri:noRegion></affiliation></author><author><name sortKey="Zernotti, Mario E" sort="Zernotti, Mario E" uniqKey="Zernotti M" first="Mario E." last="Zernotti">Mario E. Zernotti</name><affiliation wicri:level="1"><nlm:aff id="aff24">Department of Otolaryngology, Catholic University of Córdoba, Córdoba, Argentina</nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Department of Otolaryngology, Catholic University of Córdoba, Córdoba</wicri:regionArea><wicri:noRegion>Córdoba</wicri:noRegion></affiliation></author></analytic><series><title level="j">Audiology & Neurotology</title><idno type="ISSN">1420-3030</idno><idno type="eISSN">1421-9700</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>While hearing aids for a contralateral routing of signals (CROS-HA) and bone conduction devices have been the traditional treatment for single-sided deafness (SSD) and asymmetric hearing loss (AHL), in recent years, cochlear implants (CIs) have increasingly become a viable treatment choice, particularly in countries where regulatory approval and reimbursement schemes are in place. Part of the reason for this shift is that the CI is the only device capable of restoring bilateral input to the auditory system and hence of possibly reinstating binaural hearing. Although several studies have independently shown that the CI is a safe and effective treatment for SSD and AHL, clinical outcome measures in those studies and across CI centers vary greatly. Only with a consistent use of defined and agreed-upon outcome measures across centers can high-level evidence be generated to assess the safety and efficacy of CIs and alternative treatments in recipients with SSD and AHL.</p></sec><sec><title>Methods</title><p>This paper presents a comparative study design and minimum outcome measures for the assessment of current treatment options in patients with SSD/AHL. The protocol was developed, discussed, and eventually agreed upon by expert panels that convened at the 2015 APSCI conference in Beijing, China, and at the CI 2016 conference in Toronto, Canada.</p></sec><sec><title>Results</title><p>A longitudinal study design comparing CROS-HA, BCD, and CI treatments is proposed. The recommended outcome measures include (1) speech in noise testing, using the same set of 3 spatial configurations to compare binaural benefits such as summation, squelch, and head shadow across devices; (2) localization testing, using stimuli that rove in both level and spectral content; (3) questionnaires to collect quality of life measures and the frequency of device use; and (4) questionnaires for assessing the impact of tinnitus before and after treatment, if applicable.</p></sec><sec><title>Conclusion</title><p>A protocol for the assessment of treatment options and outcomes in recipients with SSD and AHL is presented. The proposed set of minimum outcome measures aims at harmonizing assessment methods across centers and thus at generating a growing body of high-level evidence for those treatment options.</p></sec></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Argentine</li><li>Australie</li><li>Autriche</li><li>Belgique</li><li>Canada</li><li>Espagne</li><li>France</li><li>Israël</li><li>Japon</li><li>Pays-Bas</li></country><region><li>Bavière</li><li>Communauté de Madrid</li><li>District de Haute-Bavière</li><li>Midi-Pyrénées</li><li>Occitanie (région administrative)</li><li>Ontario</li><li>Province d'Anvers</li><li>Région flamande</li><li>Vienne (Autriche)</li></region><settlement><li>Anvers</li><li>Madrid</li><li>Munich</li><li>Toronto</li><li>Toulouse</li><li>Vienne (Autriche)</li></settlement><orgName><li>Université d'Anvers</li><li>Université de Toronto</li></orgName></list><tree><noCountry><name sortKey="Henkin, Yael" sort="Henkin, Yael" uniqKey="Henkin Y" first="Yael" last="Henkin">Yael Henkin</name></noCountry><country name="Belgique"><noRegion><name sortKey="Van De Heyning, Paul" sort="Van De Heyning, Paul" uniqKey="Van De Heyning P" first="Paul" last="Van De Heyning">Paul Van De Heyning</name></noRegion><name sortKey="Mertens, Griet" sort="Mertens, Griet" uniqKey="Mertens G" first="Griet" last="Mertens">Griet Mertens</name><name sortKey="Mertens, Griet" sort="Mertens, Griet" uniqKey="Mertens G" first="Griet" last="Mertens">Griet Mertens</name><name sortKey="Van De Heyning, Paul" sort="Van De Heyning, Paul" uniqKey="Van De Heyning P" first="Paul" last="Van De Heyning">Paul Van De Heyning</name><name sortKey="Van Rompaey, Vincent" sort="Van Rompaey, Vincent" uniqKey="Van Rompaey V" first="Vincent" last="Van Rompaey">Vincent Van Rompaey</name><name sortKey="Van Rompaey, Vincent" sort="Van Rompaey, Vincent" uniqKey="Van Rompaey V" first="Vincent" last="Van Rompaey">Vincent Van Rompaey</name></country><country name="Australie"><noRegion><name sortKey="Tavora Vieira, Dayse" sort="Tavora Vieira, Dayse" uniqKey="Tavora Vieira D" first="Dayse" last="Távora-Vieira">Dayse Távora-Vieira</name></noRegion><name sortKey="Rajan, Gunesh P" sort="Rajan, Gunesh P" uniqKey="Rajan G" first="Gunesh P." last="Rajan">Gunesh P. Rajan</name><name sortKey="Rajan, Gunesh P" sort="Rajan, Gunesh P" uniqKey="Rajan G" first="Gunesh P." last="Rajan">Gunesh P. Rajan</name><name sortKey="Tavora Vieira, Dayse" sort="Tavora Vieira, Dayse" uniqKey="Tavora Vieira D" first="Dayse" last="Távora-Vieira">Dayse Távora-Vieira</name></country><country name="Allemagne"><region name="Bavière"><name sortKey="Muller, Joachim" sort="Muller, Joachim" uniqKey="Muller J" first="Joachim" last="Müller">Joachim Müller</name></region><name sortKey="Hempel, John Martin" sort="Hempel, John Martin" uniqKey="Hempel J" first="John Martin" last="Hempel">John Martin Hempel</name><name sortKey="Leander, Daniel" sort="Leander, Daniel" uniqKey="Leander D" first="Daniel" last="Leander">Daniel Leander</name><name sortKey="Polterauer, Daniel" sort="Polterauer, Daniel" uniqKey="Polterauer D" first="Daniel" last="Polterauer">Daniel Polterauer</name></country><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Marx, Mathieu" sort="Marx, Mathieu" uniqKey="Marx M" first="Mathieu" last="Marx">Mathieu Marx</name></region></country><country name="Japon"><noRegion><name sortKey="Usami, Shin Ichi" sort="Usami, Shin Ichi" uniqKey="Usami S" first="Shin-Ichi" last="Usami">Shin-Ichi Usami</name></noRegion><name sortKey="Kitoh, Ryosuke" sort="Kitoh, Ryosuke" uniqKey="Kitoh R" first="Ryosuke" last="Kitoh">Ryosuke Kitoh</name><name sortKey="Miyagawa, Maiko" sort="Miyagawa, Maiko" uniqKey="Miyagawa M" first="Maiko" last="Miyagawa">Maiko Miyagawa</name><name sortKey="Moteki, Hideaki" sort="Moteki, Hideaki" uniqKey="Moteki H" first="Hideaki" last="Moteki">Hideaki Moteki</name></country><country name="Canada"><region name="Ontario"><name sortKey="Smilsky, Kari" sort="Smilsky, Kari" uniqKey="Smilsky K" first="Kari" last="Smilsky">Kari Smilsky</name></region></country><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Baumgartner, Wolf Dieter" sort="Baumgartner, Wolf Dieter" uniqKey="Baumgartner W" first="Wolf-Dieter" last="Baumgartner">Wolf-Dieter Baumgartner</name></region></country><country name="Pays-Bas"><noRegion><name sortKey="Keintzel, Thomas Georg" sort="Keintzel, Thomas Georg" uniqKey="Keintzel T" first="Thomas Georg" last="Keintzel">Thomas Georg Keintzel</name></noRegion><name sortKey="Arndt, Susan" sort="Arndt, Susan" uniqKey="Arndt S" first="Susan" last="Arndt">Susan Arndt</name><name sortKey="Baumann, Uwe" sort="Baumann, Uwe" uniqKey="Baumann U" first="Uwe" last="Baumann">Uwe Baumann</name><name sortKey="George, Erwin" sort="George, Erwin" uniqKey="George E" first="Erwin" last="George">Erwin George</name><name sortKey="Hagen, Rudolf" sort="Hagen, Rudolf" uniqKey="Hagen R" first="Rudolf" last="Hagen">Rudolf Hagen</name><name sortKey="Kurz, Anja" sort="Kurz, Anja" uniqKey="Kurz A" first="Anja" last="Kurz">Anja Kurz</name><name sortKey="Rader, Tobias" sort="Rader, Tobias" uniqKey="Rader T" first="Tobias" last="Rader">Tobias Rader</name><name sortKey="Rak, Kristen" sort="Rak, Kristen" uniqKey="Rak K" first="Kristen" last="Rak">Kristen Rak</name><name sortKey="Sprinzl, Georg Mathias" sort="Sprinzl, Georg Mathias" uniqKey="Sprinzl G" first="Georg Mathias" last="Sprinzl">Georg Mathias Sprinzl</name><name sortKey="Stokroos, Robert" sort="Stokroos, Robert" uniqKey="Stokroos R" first="Robert" last="Stokroos">Robert Stokroos</name><name sortKey="Weissgerber, Tobias" sort="Weissgerber, Tobias" uniqKey="Weissgerber T" first="Tobias" last="Weissgerber">Tobias Weissgerber</name><name sortKey="Wesarg, Thomas" sort="Wesarg, Thomas" uniqKey="Wesarg T" first="Thomas" last="Wesarg">Thomas Wesarg</name><name sortKey="Wolf Magele, Astrid" sort="Wolf Magele, Astrid" uniqKey="Wolf Magele A" first="Astrid" last="Wolf-Magele">Astrid Wolf-Magele</name><name sortKey="Zirn, Stefan" sort="Zirn, Stefan" uniqKey="Zirn S" first="Stefan" last="Zirn">Stefan Zirn</name><name sortKey="Zirn, Stefan" sort="Zirn, Stefan" uniqKey="Zirn S" first="Stefan" last="Zirn">Stefan Zirn</name></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Polo, Ruben" sort="Polo, Ruben" uniqKey="Polo R" first="Ruben" last="Polo">Ruben Polo</name></region><name sortKey="Medina, Maria Del Mar" sort="Medina, Maria Del Mar" uniqKey="Medina M" first="María Del Mar" last="Medina">María Del Mar Medina</name></country><country name="Israël"><noRegion><name sortKey="Hilly, Ohad" sort="Hilly, Ohad" uniqKey="Hilly O" first="Ohad" last="Hilly">Ohad Hilly</name></noRegion><name sortKey="Ulanovski, David" sort="Ulanovski, David" uniqKey="Ulanovski D" first="David" last="Ulanovski">David Ulanovski</name></country><country name="Argentine"><noRegion><name sortKey="Rajeswaran, Ranjith" sort="Rajeswaran, Ranjith" uniqKey="Rajeswaran R" first="Ranjith" last="Rajeswaran">Ranjith Rajeswaran</name></noRegion><name sortKey="Di Gregorio, Maria Fernanda" sort="Di Gregorio, Maria Fernanda" uniqKey="Di Gregorio M" first="Maria Fernanda" last="Di Gregorio">Maria Fernanda Di Gregorio</name><name sortKey="Kameswaran, Mohan" sort="Kameswaran, Mohan" uniqKey="Kameswaran M" first="Mohan" last="Kameswaran">Mohan Kameswaran</name><name sortKey="Zernotti, Mario E" sort="Zernotti, Mario E" uniqKey="Zernotti M" first="Mario E." last="Zernotti">Mario E. Zernotti</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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